癌变·畸变·突变 ›› 2005, Vol. 17 ›› Issue (1): 54-55.doi: 10.3969/j.issn.1004-616x.2005.01.018

• 检测研究 • 上一篇    下一篇

龙葵果的急性毒性和遗传毒性试验

赖亚辉;马忠春;闫慧毅;毛焕新   

  1. 北华大学医学院, 吉林 吉林 132013
  • 收稿日期:2004-08-20 修回日期:2004-10-25 出版日期:2005-01-30 发布日期:2005-01-30
  • 通讯作者: 赖亚辉

Acute Toxicity and Genetic Toxicity Tests of Solanum Nigrum L Juice

LAI Ya-hui;MA Zhong-chun;YAN Hui-yi;et al   

  1. Medical College of Beihua University,Jilin 132013,China
  • Received:2004-08-20 Revised:2004-10-25 Online:2005-01-30 Published:2005-01-30
  • Contact: LAI Ya-hui

摘要: 背景与目地:研究龙葵果的急性毒性和遗传毒性,为龙葵果汁作为保健食品进一步开发的利用打下基础。 材料与方法: 小鼠急性毒性试Ames试验、微核试验和精子畸形试验采用《保健食品安全性评价程序和检验方法规范》要求进行。 结果: 龙葵果汁急性分组属于无毒级别。Ames试验、微核试验和精子畸形试验结果均为阴性。结论: 在本次实验条件下,未见小鼠口服急性毒性和遗传毒性作用。

关键词: 龙葵果, 遗传毒性, Ames试验, 微核试验, 精子畸形试验

Abstract: BACKGROUND & AIM: To study the acute toxicity and genetic toxicity of Solanum nigrum L juice. MATERIAL AND METHODS: Acute toxicity test of mice ,Ames test, micronucleus rest of bone marrow PCE cell in mice, sperm shape abnormality test of mice. RESULTS: Solanum Nigrum L Juice was a substance with no toxicity according to the acute toxicity. The results of genetic toxicity tests were all negative, including Ames test ,micronucleus rest and sperm shape abnormality test. CONCLUSION: Solanum Nigrum L Juice was a substance with no toxicity and had no genetic toxicity in this test.

Key words: Solanum nigrum L juice, genetic toxicity, Ames test, micronucleus test, sperm shape abnormality test